Professor of Pharmacology at Medical College of Georgia, Augusta University
Professor of Medicine at Medical College of Georgia, Augusta University
Research Interests : Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Hypertension, Lung Injury and Repair
Dr. Su’s research lab is to studythe regulatory mechanisms of airway and pulmonary circulation. The labfirst demonstrated that calpain participates VEGF-induced angiogenesis and plays an important role in airway and pulmonary vascular remodeling. Dr. Su’s research labhas been the first to discover and characterize the interaction of endothelial nitric oxide synthase to cytoskeleton protein actin. The lab has first identified the actin binding site on endothelial nitric oxide synthase protein and developed peptide P326TAT that can block the interaction of endothelial nitric oxide synthase to β-actin in lung endothelial cells and reduce the oxidative lung injuries in the side-effects of oxygen therapy. The current research is focused on airway and pulmonary vascular remodeling in COPD, lung endothelial barrier, lung injury and repair in tobacco smoke exposure. Through multidisciplinary approaches at the levels of molecule, cell, organ, whole body and patients, the goal is to find novel mechanisms, new therapeutic strategies and biomarkers for lung injury, COPD, and pulmonary hypertension.